Similac Pro Total Comfort [Review]

Similac Pro Total Comfort Review

It’s not easy to find the right formula when your newborn has a sensitive stomach. And there is not a single infant formula that works for every situation. However, some formulas have good reputations, like Similac Pro Total Comfort formula. If your baby has a delicate tummy or struggles to digest breast milk or other types of milk-based formula, this Similac formula is a good option to try.

What makes Similac Pro Total Comfort so Special?

similac pro total comfort-brain development-immune support

The formula is very impressive as a breast milk substitute. This means it contains all the critical elements for development and nutrition, which is typically associated with breast milk. It is a general opinion that breast milk will always be the best, but there are circumstances when a substitute is necessary.

Why do some babies find it harder to digest breast milk? There is no single answer. Instead, everything depends on the specific needs of the baby, and complications like allergens can make natural breastfeeding nearly impossible. But this is what Similac Pro Total Comfort is for.  It’s a good choice if your child has difficulty tolerating other milk-based formulas.

Pro-Total Comfort is also Similac’s most gentle formula with 2′-FL HMO, which is a pre-biotic that helps strengthen babies’ immune systems. 2′-FL HMO is an immune-nourishing prebiotic like that found in breast milk that helps support baby’s developing immune system.

Not only does it contain the right amount of iron power, carbohydrates, healthy fats, protein, vitamins, and minerals. But it also comes with an exclusive blend of DHA, Lutein, and vitamin E.

The result is an easy-to-digest formula that is:

  • Fully nutritional
  • Promotes a strong immune system
  • Supports brain and eye development.
  • Promotes strong bones with excellent calcium absorption
  • Helps with overall growth.

Human Milk Oligosaccharide (HMO)

Similac pro total comfort HMO

Similac Pro Total Comfort is unique in the sense that it uses Human Milk Oligosaccharide (HMO). And while this ingredient does not come from humans, it is a prebiotic with immune-nourishing properties similar to breast milk. Also, the formula contains partially hydrolyzed protein, which makes it much easier for the baby to digest.

The HMO ingredient is responsible for feeding the good bacteria located in the stomach. And given that the gut makes up 70% of your baby’s immune system, it is logical why the formula has so many glowing reviews.

Pro-Total Comfort is a good choice for babies with trouble tolerating other milk-derived formulas.

For some parents, the fussiness and discomfort their babies experienced were gone in only 24-hours. But these are not results that can be guaranteed for your baby if Similac Pro Total Comfort is not right for them, because some parents only saw a difference after a week.

What does Non-GMO mean?

It should be noted that Similac has made a significant change to the formula recently. They have switched to non-GMO (Genetically Modified Organism) ingredients. So, the same ingredients are used, but they are not sourced from products with scientifically altered DNA. For example, the dairy ingredients only come from cows that have not been treated with artificial hormones.

The fact is some parents prefer a more natural approach. Even though there are several benefits to using GMO ingredients, but they also have possible risks, such as introducing unknown allergens. Also, without mandatory testing in place for formulas, there can be unknown side-effects that have not been officially recorded.

Similac Pro Total Comfort vs Breast Milk

As mentioned earlier, the formula has everything your baby needs. But when do pediatricians recommend formula over breast milk?

Well, it is the perfect alternative if your baby is lactose intolerant, seeing as it contains less than 2% lactose. But it is also gentle enough to combat acid reflux, and like breastmilk it promotes healthy bowel movements if constipation is a problem.

And there is also the matter of the baby being allergic to something in mom’s diet. If this is the case, then finding the source of the problem can be very complex. More specifically, it takes too long.

Similac Pro Total Comfort Features

  • Partially hydrolyzed protein for easy digestion
  • Less than 2% lactose, making it a great alternative for lactose intolerant babies
  • Fights acid reflux thanks to the gentle ingredients and special blend
  • Clear instructions on how to mix and prepare the formula
  • Helps with constipation and promotes healthy bowel movements

Special Considerations

While the majority of mothers agree that Similac Pro Total Comfort can be a miracle formula, there is a chance that you get a different reaction.

  • Stinky blowouts
    It is great to prevent constipation, but when it turns to stinky blowouts then you might want to get back to your pediatrician.
  • It might cause gas or constipation
    If your baby has problems with gas, there is a small risk this particular formula can make it worse. At the same time, it could lead to constipation.
  • Limited to 30-day shelf life
    Some might consider Similac Pro Total Comfort to be expensive, considering you have to use the formula within 30-day after opening the container.

Feedback and opinions from mothers

This particular infant formula enjoys significantly more positive reviews than negative ones. Most parents found that the formula helped to ease their baby fairly quickly. In other words, fussiness and crying dissipated while digestion improved and stabilized.

A selected few, on the other hand, did report negative reactions to the formula. In one case, the mother pointed to the change in using non-GMO, which is generally preferred by most but she prefers the original Similac Total formula.

Overall, the brand is well respected by pediatricians and parents in general. This makes it worth trying if you find yourself looking for a breast milk (or another milk-based formula) substitute.

Our Final Verdict

With no genetically modified ingredients, Similac Total pro comfort formula is as natural as you are going to get in terms of substituting breastfeeding. Given the hugely positive reviews out there, it is worth the test. Always consult with your pediatrician if you are unsure or switching doesn’t help.

Similac also has a Similac formula finder tool to help you find the best similac formula to use for your baby. If you like the Similac range then definitely try it out as it helps guide you better to the correct formula to use.

Frequently asked questions

Does similac total comfort have lactose?

Answer: Similac pro total comfort contains less than 2% lactose and is therefore a good formula option for babies that are lactose intolerant.

Is Similac pro total comfort the same as total comfort?

Answer: Similac Pro Total Comfort formula contains more prebiotics than the regular Total Comfort formula. Prebiotics are substances that promote the growth of healthy bacteria in the gut, so this can be helpful for infants who are struggling with digestive problems. The Pro Similac line also has HMO (human milk oligosaccharide) that is an immune-boosting carbohydrate found in breast milk.

Otherwise, there is no huge difference between the two, as both are meant to provide complete comfort and nutrition to your baby. They are both made more for babies that struggle to tolerate other milk-based formulas due to lactose sensitivity. very similar and will provide all the nutrients your baby needs.

Can similac total comfort cause constipation?

Answer: Yes, it’s possible that Similac Total Comfort could cause constipation. This is because the formula is designed to be gentle on your baby’s stomach and may not have enough fiber to help with regular bowel movements. Some parents have reported that their babies had constipation after switching to this formula, while others haven’t had any problems. If your baby experiences constipation after switching to this formula, you may want to try a different type of formula or consult with your pediatrician.

Ingredients And Nutrition Information

Powder / 1.45 lb
Serving size: 100 Cal (5.3 fl oz, prepared as directed)
Amount per serving
Calories: 100
Volume, mL: 156
Protein, g: 2.32
Fat, g: 5.4
Carbohydrate, g: 11
Water, g: 141
Linoleic Acid, mg: 1000


Vitamin A, IU: 300
Vitamin D, IU: 60
Vitamin E, IU: 1.5
Vitamin K, mcg: 8
Thiamin (Vitamin B1), mcg: 100
Riboflavin (Vitamin B2), mcg: 160
Vitamin B6, mcg: 63
Vitamin B12, mcg: 0.26
Niacin, mcg: 1100
Folic Acid (Folacin), mcg: 16
Pantothenic Acid, mcg: 470
Biotin, mcg: 4.6
Vitamin C (Ascorbic Acid), mg: 9
Choline, mg: 24
Inositol, mg: 4.5


Calcium, mg: 105
Calcium, mEq: 5.3
Phosphorus, mg: 70
Magnesium, mg: 6
Iron, mg: 1.9
Zinc, mg: 0.79
Manganese, mcg: 5
Copper, mcg: 95
Iodine, mcg: 9
Selenium, mcg: 2
Sodium, mg: 46
Sodium, mEq: 2
Potassium, mg: 121
Potassium, mEq: 3.1
Chloride, mg: 68
Chloride, mEq: 1.9


It contains milk ingredients.
Corn Maltodextrin, Whey Protein Hydrolysate, High Oleic Safflower Oil, Sugar, Soy Oil, Coconut Oil. Less than 2% of: C. Cohnii Oil, M. Alpina Oil, 2′-Fucosyllactose, Short-Chain Fructooligosaccharides, Beta-Carotene, Lutein, Lycopene, Calcium Citrate, Potassium Phosphate, Calcium Phosphate, Magnesium Chloride, Salt, Potassium Citrate, Ascorbic Acid, Choline Chloride, Sodium Citrate, Potassium Chloride, Calcium Hydroxide, Ferrous Sulfate, Taurine, m-Inositol, Choline Bitartrate, Zinc Sulfate, Ascorbyl Palmitate, L-Carnitine, Niacinamide, Mixed Tocopherols, d-Alpha-Tocopheryl Acetate, Calcium Pantothenate, Copper Sulfate, Vitamin A Palmitate, Thiamine Hydrochloride, Riboflavin, Pyridoxine Hydrochloride, Folic Acid, Manganese Sulfate, Phylloquinone, Potassium Iodide, Biotin, Sodium Selenate, Vitamin D3, Vitamin B12, Potassium Hydroxide, and Nucleotides (Adenosine 5’-Monophosphate, Cytidine 5’-Monophosphate, Disodium Guanosine 5’-Monophosphate, Disodium Uridine 5’-Monophosphate).

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